Synthio Chemicals, LLC


Process design for the chemical process, pharmaceutical and energy storage industries.

Areas of Expertise


The use of fluorinated products is expanding rapidly. More than 30% of recently approved pharmaceuticals contain fluorine, and the percentage is even higher in agrochemicals. However, handling hydrogen fluoride and fluorine requires specialized equipment and expertise that few companies have. Synthio has years of experience in fluorine chemistry, and our process intensification allows exceptionally compact reactors with dramatic safety benefits. Contact us to see how we can transform your fluorination system.



Custom chemical manufacturing

Synthio Chemicals manufactures fine and specialty chemicals using its own proprietary equipment and synthetic routes. Our capabilities range from kilograms to hundreds of tons, with a sweet spot in the tons-per-year range. Our current production capabilities include nitric acid oxidation to produce carboxylic acids, specialty fluorinations, and synthesis of high-purity ionic liquids. 


Ionic liquids with fluorinated anions are among the most electrochemically and thermally stable solvents known today. With electrochemical windows up to 5.5 V, and thermal stability over 250°C, these versatile fluids enable devices and process unobtainable with other solvents. Synthio produces ionic liquids in electrochemical grade with unique continuous production systems. Our extensive knowledge of both ionic liquid electrochemistry and production methods allows us to quickly identify IL that will both provide outstanding performance and meet cost targets. 



Continuous synthesis train design and Fabrication

In addition to building custom reactors for its own use, Synthio also constructs synthetic trains for customers. Our typical designs integrate multiple unit operations in a single continuous flow system, enabling reductions of up to two orders of magnitude in system size. We utilize robust, sophisticated computerized control systems to enable 24/7 unattended operations while meeting all applicable safety standards. Custom Synthio reactor systems are typically sold in conjunction with a license to our patented and trade secret intellectual property. 


As a newly recognized field of chemical engineering, process intensification (PI) encompasses two different approaches to radical improvements in chemical processes. The first approach reduces rate limiting influences of heat and mass transfer or chemical kinetics on processes through innovative reactor and equipment design. The second approach combines multiple process steps in a single operation often removing equilibrium limitations or radically simplifying an overall process. We have demonstrated successes in both of these PI approaches for a variety of applications. Our analytical modeling capabilities allow process scoping to quickly identify promising PI techniques which are validated in-house through careful pilot testing. Our expertise includes advanced fabrication techniques including microchannel devices. 


Synthio's deep expertise in ionic liquids, electrolytes and process intensification makes us ideal partners for customers seeking to evaluate IP in these areas, in the context of investment, acquisition, sale, or competitive analysis. Synthio staff maintain subscriptions to leading patent analysis software, making us cost-effective expert partners to your next deal. Contact us to see how we can help you understand the patent landscape int these areas.